Episode 27: High Grade Gliomas and Glioblastoma Multiforme (GBM)

Concluding their Journey to the Centre of the Brain, Michael and Josh tackle one of the most challenging and difficult cancers in modern oncology: high-grade gliomas. All of the usual suspects are here: irrevocable, progressive disease, limited treatment options and a gulf in evidence so large it makes the Grand Canyon look like a muddy footprint. All in all, not the most optimistic of OftiM episodes, but Josh and Michael will tackle it anyway so you don't have to. And remember: always refer your fit GBM patients to a friendly neighbourhood trials unit near you!

Links to studies discussed in this episode (subscription may be required):

EORTC 26981-22981 NCIC CE3 (aka the “Stupp study"): https://www.nejm.org/doi/full/10.1056/nejmoa043330

RTOG 0825: https://www.nejm.org/doi/full/10.1056/nejmoa1308573

Brada et al: https://ascopubs.org/doi/full/10.1200/JCO.2009.27.1932?role=tab

Taal et al: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(14)70314-6/fulltext

Wick et al: https://www.nejm.org/doi/full/10.1056/nejmoa1707358